Rapid viral quasispecies evolution: implications for vaccine and drug strategies
Identifieur interne : 000502 ( Istex/Curation ); précédent : 000501; suivant : 000503Rapid viral quasispecies evolution: implications for vaccine and drug strategies
Auteurs : Isabel S. Novella [États-Unis] ; Esteban Domingo ; John J. Holland [États-Unis]Source :
- Molecular Medicine Today [ 1357-4310 ] ; 1995.
English descriptors
- Teeft :
- Antiviral, Antiviral agents, Antiviral drugs, Complete shift, Diverse quasispecies populations, Encephalitis, Environmental conditions, Epitope, Error threshold, Genome, Hemorrhagic, Human immunodeficiency virus, Human immunodeficiency virus type, Immune, Immune response, Influenza, Limited number, Measles, Mutant, Mutation, Mutation rates, Original variant, Partial shift, Peptide vaccines, Quasispecies, Rapid evolution, Raven press, Replication, Resistant mutants, Subacute sclerosing panencephalitis, Such mutants, Vaccine, Vaccine design, Vaccine development, Viral, Viral proteins, Viral quasispecies, Virus, Virus infections, Virus quasispecies, Virus vaccines.
Abstract
High mutation rates occurring during replication allow RNA viruses to evolve rapidly and adapt continuously to new environments. This poses an enormous challenge to vaccine and drug development which, to be effective, must consid RNA virus variability and follow approaches that minimize the probability of escape or resistant mutants arising.
Url:
DOI: 10.1016/S1357-4310(95)91551-6
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Esteban Domingo<affiliation><mods:affiliation>Centro de Biologia Molecular “Severo Ochoa” (Consejo Superior de Investigaciones Cientificas) Universidad Autonoma de Madrid Cantoblanco 28049 Madrid Spain.</mods:affiliation><wicri:noCountry code="no comma">Centro de Biologia Molecular “Severo Ochoa” (Consejo Superior de Investigaciones Cientificas) Universidad Autonoma de Madrid Cantoblanco 28049 Madrid Spain.</wicri:noCountry></affiliation>Le document en format XML
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Novella</name><affiliation><mods:affiliation>Department of Biology and Institute for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093-0016, USA. Tel: +1 619 534 2520 Fax: +1 619 534 7108</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: isabel@jeeves.ucsd.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Domingo, Esteban" sort="Domingo, Esteban" uniqKey="Domingo E" first="Esteban" last="Domingo">Esteban Domingo</name><affiliation><mods:affiliation>Centro de Biologia Molecular “Severo Ochoa” (Consejo Superior de Investigaciones Cientificas) Universidad Autonoma de Madrid Cantoblanco 28049 Madrid Spain.</mods:affiliation><wicri:noCountry code="no comma">Centro de Biologia Molecular “Severo Ochoa” (Consejo Superior de Investigaciones Cientificas) Universidad Autonoma de Madrid Cantoblanco 28049 Madrid Spain.</wicri:noCountry></affiliation></author><author><name sortKey="Holland, John J" sort="Holland, John J" uniqKey="Holland J" first="John J." last="Holland">John J. Holland</name><affiliation wicri:level="1"><mods:affiliation>Department of Biology and Institute for Molecular Genetics, University of California, San Diego, CA, USA.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biology and Institute for Molecular Genetics, University of California, San Diego, CA</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Molecular Medicine Today</title><title level="j" type="abbrev">MOLTOD</title><idno type="ISSN">1357-4310</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">1</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="248">248</biblScope><biblScope unit="page" to="253">253</biblScope></imprint><idno type="ISSN">1357-4310</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1357-4310</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antiviral</term><term>Antiviral agents</term><term>Antiviral drugs</term><term>Complete shift</term><term>Diverse quasispecies populations</term><term>Encephalitis</term><term>Environmental conditions</term><term>Epitope</term><term>Error threshold</term><term>Genome</term><term>Hemorrhagic</term><term>Human immunodeficiency virus</term><term>Human immunodeficiency virus type</term><term>Immune</term><term>Immune response</term><term>Influenza</term><term>Limited number</term><term>Measles</term><term>Mutant</term><term>Mutation</term><term>Mutation rates</term><term>Original variant</term><term>Partial shift</term><term>Peptide vaccines</term><term>Quasispecies</term><term>Rapid evolution</term><term>Raven press</term><term>Replication</term><term>Resistant mutants</term><term>Subacute sclerosing panencephalitis</term><term>Such mutants</term><term>Vaccine</term><term>Vaccine design</term><term>Vaccine development</term><term>Viral</term><term>Viral proteins</term><term>Viral quasispecies</term><term>Virus</term><term>Virus infections</term><term>Virus quasispecies</term><term>Virus vaccines</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High mutation rates occurring during replication allow RNA viruses to evolve rapidly and adapt continuously to new environments. 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